The adoption of this possible undesirable action is a clear violation of the FCTC Article 5.3 where public health policies on tobacco control are being challenged by entities of commercial and vested interest. NCWO is of the view that the Government should not be put under such pressure for the following reasons. 1. The evidence is staggering; tobacco kills one person every six seconds – that is, one in 10 deaths among adults worldwide – and accounts for 500 million deaths a year. By 2030, unless urgent action is taken, tobacco’s annual death toll will rise to more than eight million. WHO in its Global Tobacco Epidemic Report 2008 warns us that if current trends continue unchecked, tobacco could kill up to one billion people in this century. 2. Every day, 50 teenagers in Malaysia begin smoking. Of the 4.7 million smokers here, most started before the age of 18, with 25% before the age of 10.
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Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. Non-smokers (n = 43) and smokers (n = 40), 22–70 years of age, completed a 4 T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions. In smokers, higher pack-years were associated with smaller volumes of the bilateral amygdala, nucleus accumbens, total corpus callosum and subcortical WM. Results provide novel evidence that chronic smoking in adults is associated with accelerated age-related volume loss in subcortical WM and GM nuclei. Greater cigarette quantity/exposure was related to smaller volumes in regions that also showed greater age-related volume loss in smokers.