In these adults, 22–70 years of age, older smokers showed the most volume loss. Subcortical white matter (WM), thalamus, cerebellar cortex, and corpus callosum were most affected. Higher cigarette pack-years related to smaller volumes in several subcortical regions. Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. Non-smokers (n = 43) and smokers (n = 40), 22–70 years of age, completed a 4 T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions.
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In North Carolina, the newspaper ads will run only in Charlotte. The nation’s three largest tobacco manufacturers have agreed on the wording and timing of federal court-ordered corrective statements about the dangers of smoking combustible cigarettes. The ads will commence Nov. 26. Full-page newspaper ads will run in major U.S. metropolitan areas, and 30- to 45-second spot ads will be shown on the ABC, CBS and NBC television networks. In North Carolina, the newspaper ads will be published only in Charlotte. The ads are projected to cost several millions of dollars for each manufacturer. R.J. Reynolds Tobacco Co. said Tuesday that it could cost $20 million to comply.
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